On November 8, 2021, Allam announced that she would be seeking the Democratic Party's nomination for Congress in North Carolina's newly redrawn 4th Congressional District.

[3] When she was five years old her family moved to Brier Creek, a suburb between Raleigh and Durham in North Carolina, after her father took a job with IBM at Research Triangle Park.

[3][10] Allam was inspired to become politically involved after her best friend, Yusor Mohammad Abu-Salha, was one of the three people killed in the 2015 Chapel Hill shooting.

[1][12][19][20] When Allam announced her candidacy for Durham County Commissioner, her family members received Islamophobic hate mail via social media platforms.

[3] She was elected to serve alongside Nimasheena Burns, Wendy Jacobs, Heidi Carter, and Brenda Howerton.

[16] On November 8, 2021, Allam announced that she would be seeking the Democratic Party's nomination for Congress in North Carolina's newly redrawn 4th Congressional District.

[2] If she were elected, she would be the third Muslim woman to serve in Congress, after Ilhan Omar and Rashida Tlaib,[27] both of whom endorsed Allam's candidacy.

Campaign priorities included a $15 minimum wage for county workers, boosting mental health services in schools and investing in businesses run by women and people of color.

[12] As a county commissioner, Allam stated she plans to increase the minimum wage of Durham Public Schools classified staff to U.S. $15 an hour and enact property tax assistance programs.

[1][16][12] She has stated that evictions and lack of affordable housing opportunities are also a crisis in the county, and referenced the issue of gentrification misplacing Black families from their homes in Durham's historical African-American neighborhoods.

[30][28] In 2021, Allam apologized to the Jewish community for her past statements and committed to "a movement for justice and peace, in which anti-Semitism must have no home.

"[31] While Allam received endorsements in her race from figures like Ilhan Omar, who have been in the past accused of antisemitism,[32] Valerie Foushee, her primary opponent, began to receive funds and assistance from pro-Israel groups such as AIPAC and Sam Bankman-Fried's Protect Our Future PAC, prompting allegations that Foushee's campaign had succeeded primarily due to support from dark money as the race became "the most expensive Democratic congressional primary in North Carolina history".