The series touches lightly upon issues of discrimination, stereotypes, social alienation, cultural assimilation and city life versus countryside living.

Mayuko, who attends a cram school, is a young girl living away from her family and expresses a lot of melancholy.

NieA, who is apparently placed in an inferior class by her fellow aliens due to being a physical minority among them, immediately accuses anyone who calls her a "stupid no-antenna" or the like, of discrimination.

Other aliens adopt various stereotypical cultural styles, such as Chada who dresses in Indian attire and opens a convenience store, or Karna who chooses to associate herself with the Chinese Revolution.

This theme of the outsider alien is carried through in the brief comic live-action sequence which ends each episode, "Dalgit's Tidbit of Indian Information."