Considered a five-star recruit and the ranked first among outside linebacker prospects by Rivals.com,[2] Bradham had numerous scholarship offers but decided to attend Florida State early in April 2007.
[9][10] Bradham began training camp competing for a roster spot as a linebacker against Arthur Moats, Chris White, Tank Carder, Bryan Scott, and Danny Batten.
[12] Head coach Chan Gailey named Bradham the backup strongside linebacker to begin the regular season, behind Arthur Moats.
On December 31, 2012, it was announced that the Buffalo Bills decided to fire head coach Chan Gailey after they did not qualify for the playoffs and finished with a 6–10 record.
[19] Head coach Doug Marrone named Bradham the backup outside linebacker to start the regular season, behind starters Arthur Moats and Manny Lawson.
[20][21] On December 8, 2013, Bradham earned his first start of the season and recorded six combined tackles during a 27–6 loss at the Tampa Bay Buccaneers in Week 14.
[23] He received the opportunity to become the starter after Kiko Alonso tore his ACL during organized team activities, Arthur Moats departed in for the Pittsburgh Steelers in free agency, and Manny Lawson was moved to defensive end.
In Week 4, he recorded four combined tackles, a pass deflection, made his first career interception, and 1.5 sacks in the Bills' 23–17 loss at the Houston Texans.
On November 30, 2014, he tied his season-high of 12 combined tackles (nine solo), deflected a pass, and recorded a sack in the Bills' 26–10 win against the Cleveland Browns in Week 13.
[18] On January 1, 2015, it was announced that head coach Doug Marrone opted to exercise a clause in his contract and resign from his role after finishing with a 9–7 record in 2014.
He started in the Buffalo Bills' season-opener against the Indianapolis Colts and recorded a season-high eight combined tackles and sacked quarterback Andrew Luck in their 27–14 victory.
On November 29, 2015, he recorded four solo tackles before exiting the Bills' 30–22 loss at the Kansas City Chiefs due to an ankle injury.
[35][36] Bradham became an unrestricted free agent after 2015 and received interest from multiple teams, including the Philadelphia Eagles, Tampa Bay Buccaneers, Cleveland Browns, and Jacksonville Jaguars.
On October 23, 2016, he made seven combined tackles, broke up a pass, and sacked quarterback Sam Bradford in the Eagles' 21–10 win against the Minnesota Vikings in Week 7.
He finished his first season with the Eagles with 102 combined tackles (69 solo), five pass deflections, two sacks, two forced fumbles, and an interception in 16 games and 16 starts.
In Week 6, Bradham recorded ten combined tackles (seven solo) and a season-high two pass deflections in the Eagles' 28–23 victory at the Carolina Panthers.
[45] The Philadelphia Eagles finished the season atop the NFC East with a 13–3 record, clinching home-field advantage and a first round bye.
On January 13, 2018, Bradham started in his first career playoff game and recorded four combined tackles, a pass deflection, and sacked quarterback Matt Ryan during a 15–10 victory against the Atlanta Falcons in the NFC Divisional Round.
[44] On February 4, 2018, Bradham started in Super Bowl LII and recorded seven combined tackles in the Eagles' 41–33 victory over the New England Patriots.
[10][46] On June 29, 2018, Bradham was suspended for the first game of the season for violating the NFL's personal conduct policy from a battery/aggravated assault incident in July 2016.
In the Eagles' week 15 game against the Washington Redskins, Bradham returned a fumble lost by Dwayne Haskins for a 46-yard touchdown in the closing seconds of the 37–27 win.
[57] Bradham was arrested in Miami on July 25, 2016 after officials say he got violent with a Hilton Bentley worker who was setting up a beach umbrella for the NFL player's group.