The film features three separate stories, presented through a frame narrative in which God and Satan view and debate the fates of the characters contained within them.

[2] The three interior segments that comprise Night Train to Terror were shot years prior and originally intended as standalone features, but went either unreleased or unfinished.

Meanwhile, the staff use a hypnotized Harry to lure various people to the hospital, including a bartender and a young woman, only to be brutally murdered.

Glenn Marshall, a medical school student, becomes enamored of Gretta after seeing one of her films, and tracks her to a Manhattan bar owned by George, where she performs as a pianist.

Weiss takes it upon himself to enact revenge by tracking the group to a large mansion, but is killed after encountering a demonic-looking woman.

Papini attempts to stop the Nazi group—who are in fact a cult of demonic apprentices to the Devil—but is captured by a monstrous creature and dragged into the earth.

Night Train to Terror was created using the salvaged footage of three other unreleased horror films that had been shot years prior.

[4] The first story, "The Case of Henry Billings", features footage from the unfinished film Scream Your Head Off (1981), directed by John Carr.

[5] The third story, "The Case of Claire Hansen", originated from the unreleased film Cataclysm (1980) directed by Phillip Marshak, Tom McGowan, and Gregg C. Tallas, which had the alternate working titles The Nightmare Never Ends and Satan's Supper.

[6] Parts of the film were shot in Salt Lake City, Utah as well as La Jolla and San Diego, California.

The film was given a limited release theatrically by Visto International in 1985, opening regionally in Knoxville, Tennessee on January 25, 1985.