Nightlife is an American syndicated half-hour late-night talk show hosted by comedian David Brenner that aired weeknights from September 8, 1986, to June 19, 1987.

[2] David Brenner was a frequent guest and regular fill-in host on Tonight, much like another comic, Joan Rivers, whose own talk show debuted a month after Nightlife.

[5] A notable exception came on October 17, 1986, when Brenner gave an extended monologue through two commercial breaks and until the closing credits.

"[12] November ratings fell to a 1.9, and by January 1987, David Smith, associate director of programming at Katz Communications, said that Nightlife would probably not return for a second season.

[13][14] King World and Motown Productions announced in April that they will complete the show's 195-episode commitment, though it was not officially cancelled for another two months.

[16] Brenner told TV columnist Gary Deeb that when ratings "didn't go through the roof" in the first month, many stations then decided to move the show from the more desirable 11:00 p.m. – midnight time periods to the middle of the night.