Nijō family (二条家, Nijō-ke) is a Japanese aristocratic kin group.

[1] The family name Nijō derived from Yoshizane's residence in Kyoto, where is believed to locate between two roads, the south of "Nijō-Ōji" (二条大路) and the east of "Higashi no Tōin-Ōji" (東洞院大路).

[3] As of the Muromachi and Edo period, Nijō family had a relative close relationship comparing with other four regent houses, and the leaders of the Nijō were given names (henki, 偏諱) from that of incumbent shōguns'.

[4] Nijō Nariyuki, the last Sesshō and Kampaku, regent from the Fujiwara clan, also came from this family.

[6] [7] The Matsuzono family (松園家, Matsuzono-ke) was founded by Ryū’on (隆温), the 19th son of Nijō Harutaka, and he was a Buddhist monk in Daijō-in [ja] from 1830 to 1868; during the Meiji era, Ryū’on took the family name Matsuzono as of 1869; he also adopted Hisayoshi, third son of his cousin Kujō Hisatada, as his heir.