Nikola Kljusev (Macedonian: Никола Кљусев; October 2, 1927 – January 16, 2008) was a Macedonian politician and professor of economics who served as the first Prime Minister of the Republic of Macedonia (now North Macedonia) from March 20, 1991, to September 5, 1992, following the country's independence from Yugoslavia in 1991.

Nikola Kljusev was born in Štip, Kingdom of Yugoslavia (now North Macedonia), on October 2, 1927.

Kljusev was elected as a member of the Macedonian Academy of Arts and Sciences (MANU) in 1988,[1] presiding over the Council of Demographic Research.

[8] The government under his leadership introduced the denar as Macedonia's new national currency, established an anti-inflation programme which fixed the currency to the German mark, created the Macedonian army, established an independent National Bank, introduced restrictive fiscal and monetary policies, imposed a wage freeze and a limited price freeze.

[14] Kljusev was buried in the Alley of the Great at the Butel cemetery in Skopje,[15] following a funeral officiated by the head of the Macedonian Christian Church, Archbishop Stephen of Ohrid.