Nikola "Nikša" Prkačin (born 15 November 1975) is a Croatian retired professional basketball player and coach.

Prkačin started his basketball club career in his hometown of Dubrovnik, where he played with the local team of Pomorac.

In 1993, at the age of 18, Prkačin moved to the Croatian Premier League club Split Croatia, where he played for the next five seasons.

Prkačin established himself as the successor to Split's famous center Dino Rađja, and during his time with the club, he also gained significant experience and knowledge.

While with Cibona Zagreb, some his teammates included: Slaven Rimac, Zoran Planinić, Josip Sesar, Dino Rađja, and Chucky Atkins After spending a decade building up his career in the Croatian Premier League, Prkačin finally signed a contract with a foreign club.

Prior to the 2008–09 season, Prkačin moved back to Croatia, as he signed a €400,000 net income annual contract with Cibona Zagreb.

Although he was shorter in height compared to most other European centers of his era, Prkačin compensated for that with his immense strength and body balance.