He is considered one of the greatest players in Olympiacos history,[1] where he scored 159 goals in 291 official games for the club.

Since retiring as a player he has become a football manager, achieving notable success at PAS Giannina, Panachaiki, Aris, OFI and Kalamata, becoming a fan favourite in these clubs.

He became known for his outspoken attitude, tactical flexibility, and success under pressure, having achieved promotions with Aris and avoiding relegation on numerous occasions.

His debut in European competition was also impressive as he scored twice against FC Twente and once against IFK Göteborg in the Cup-winners' Cup.

Though he performed well in the Italian Cup, he failed to score a single goal in Serie A and returned to Greece the following season.

On 21 September 1977, Anastopoulos made his debut for Greece and during his playing career he was capped 75 times[3] scoring 29 goals – more than any other Greek international.