Niño was born by Alexander Muhlach and Rebecca Rocha, he has five siblings.
A nephew of Amalia Fuentes and Álvaro Muhlach, his cousins Aga and Arlene are also actors.
He was dubbed the "Child Wonder of the Philippines" for making films that garnered both critical and commercial success.
He holds the title of highest-paid child actor in the history of Filipino cinema.
He is currently owner of Megamelt Bakeshop, home of Muhlach Ensaymada located at Nicanor Domingo Street corner Mayor Ignacio Santos Díaz Street in the Cubao District of Quezon City.