Nipissing District is a district in Northeastern Ontario in the Canadian province of Ontario.

The district seat is North Bay.

The land area is 16,986.20 square kilometres (6,558.41 sq mi); the population density was 5.0 per square kilometre (13/sq mi), making it one of the most densely populated districts in northern Ontario.

City: Towns: In addition, the eastern part of the town of Kearney is within Nipissing District, but the entire town is enumerated with the Parry Sound District.

Townships: Unorganized areas: As a census division in the 2021 Census of Population conducted by Statistics Canada, the Nipissing District had a population of 84,716 living in 37,252 of its 41,974 total private dwellings, a change of 1.9% from its 2016 population of 83,150.