The Nishikyushu Expressway (西九州自動車道, Nishi-Kyūshū jidōshadō) is one of the expressways of Japan which goes from Fukuoka to Takeo, running through the prefecture of Saga and the northern half of the Nagasaki Prefecture.

The Takeo and Sasebo toll zone is managed by West Nippon Expressway Company.

This road is connected to Fukuoka Expressway Circular Route in Nishi-ku, Fukuoka, and to Nagasaki Expressway in Takeo.

After this, most of the incomplete areas were to be built according to the New Direct Control System, whereby the burden for construction costs will be shared by the national and local governments and no tolls were to be collected.

The expressway is four lanes wide from Fukushige Junction to Higashi Intersection (temporary interchange) and Saza Interchange to Sasebo Chūō Interchange, and two lanes for all remaining sections.