[3] The date of the first Nissena Cup dates back to May 24, 1922, on the occasion of the inauguration of the war memorial of the Great War, in Viale Regina Margherita in Caltanissetta.

The route of the time was 166.6 km long, which would be covered in two turns, starting with via Sant'Anna and reaching Imera, passing through Capodarso and Castrogiovanni (today Enna).

The first edition was won by Luigi López, with an Itala.

[4] The Nissena Cup for the outbreak of World War II in the first place, but also for organizational reasons, disappears from the calendar for 25 years.

The return was only in 1949, with a new formula: hillclimbing and the route is shortened to only 12 km.