Nister-Möhrendorf is an Ortsgemeinde – a community belonging to a Verbandsgemeinde – in the Westerwaldkreis in Rhineland-Palatinate, Germany.

Nister-Möhrendorf belongs to the Verbandsgemeinde of Rennerod, a kind of collective municipality.

Running right through the community is Bundesstraße 414, leading from Herborn to Hachenburg.

The nearest InterCityExpress stop is the railway station at Montabaur on the Cologne-Frankfurt high-speed rail line.

In Nister-Möhrendorf, the primary school 'Hoher Westerwald' and a kindergarten are located.