At this time, producer of New Theatres, B. N. Sircar asked Nitin Bose to venture into film direction.

[1] Bose's first movie under Bombay Talkies banner was Naukadubi (1947), based on Tagore's novel of the same name.

Hindi version of this film was named Milan, in which Dilip Kumar acted in the lead role.

His next film Drishtidan (1948) introduced Uttam Kumar, who later became superstar of Bengali Cinema.

Ganga Jamuna (1961), directed by Bose, is still considered one of the all-time blockbusters of Indian Cinema.

Satyajit Ray was a nephew of Bose and worked under him in the movie Mashaal (1950), which was produced by Bombay Talkies.

[8] He leaves behind his wife Santi Bose, daughters Rina and Neeta and 6 grandchildren and 8 great-grandchildren.