After completing eight years of standard education, she dropped out of school and joined a taxi centre where a customer, a producer of Television Maldives, offered her to make her career debut with the drama series Hithi Thajuribaa (1994).

[1] A die-hard fan of Amitabh Bachchan, Rekha, Aamir Khan, and Kajol, she frequently listened to Voice of Maldives and watched Bollywood films, which inspired her to become an actress.

[1] The next year, she joined a taxi centre and four months later, she received a call from Mariyam Shauqee, a producer for Television Maldives, praising her voice and offering to cast Mohamed in one of her films.

At the age of seventeen, the young actress made her career debut in Shaugee's television drama series Hithi Thajuribaa (1994) alongside Ali Shameel, Aminath Rasheedha, and Arifa Ibrahim.

[1][3] In the former, she starred alongside Hamid Ali, Hussain Sobah, and Waleedha Waleed while playing the role of Shiuna, the charismatic and intelligent teenage daughter of a wealthy businessman who is being duped in a series of unfortunate events.

[9] Mohamed then starred opposite Reeko Moosa Manik, Hassan Afeef, and Mariyam Nazima in Easa Shareef's Emme Fahu Dhuvas (2000), where she played a devious woman who spoils her best friend's upcoming marriage by creating false accusation and staging misleading impressions.

[7] The following year, she played the role of Mary, a devoted wife desperately seeking affection from her husband in Abdul Faththaah's television drama series Dhoapatta (2000).

[11] Mohamed's collaboration with Faththaah was repeated the same year with another romantic drama series, Aisha, where she played the helpful friend of a young woman suffering from an abusive marriage.

[12] Mariyam Shauqee's widely acclaimed family drama television series Kahthiri was released in 1997; here Mohamed played the role of a doctor living in a congested housing complex while dealing with various social issues.

[13] In 2000, Mohamed played Fazlee Shareef, an unattractive fun-loving tomboy who later transforms into a feminine and beautiful girl, and who is secretly in love with her best friend, in Hussain Adil's romance Hiyy Halaaku.

[16] The Amjad Ibrahim-directed Ainbehge Loabi Firiehge Vaajib, starring Mohamed, Yoosuf Shafeeu, Jamsheedha Ahmed, and Arifa Ibrahim was released the same year.

[17] This was followed by the year's most successful Maldivian film, Ahmed Nimal's horror classic Zalzalaa, in which Mohamed portrays the character of Shiuna Ibrahim, an innocent and amenable young woman who marries a divorcee.

[22] Cast opposite Ali Seezan, Sheela Najeeb, and Asad Shareef, Mohamed played the role of Leena, the partner of a wealthy businessman who secretly loves him for a long time.

[23] Niuma collaborated with Easa Shareef once again for another horror film, titled Ginihila (2003), alongside Ali Seezan, Mariyam Nisha, and Reeko Moosa Manik, playing the role of Suhana, a mentally unstable young girl who commits suicide when her boyfriend rejects her demand to leave his wife for her.

[27] Featuring Hassan, Yoosuf Shafeeu, Sheela Najeeb, Sheereen Abdul Wahid, Amira Ismail, and Aminath Rasheedha, the film received mainly negative reviews from critics, though its inclusion of the theme portraying the relationship between a couple with a large age gap was praised.

[28] Mohamed was later applauded for her performance as Faraha, an empowered, wealthy business woman who makes it her life's mission to break up a happy marriage in the Abdul Faththaah-directed critically acclaimed television series Thiyey Mihithuge Vindhakee (2003).

[32][33] This was followed by Abdul Faththaah's Aan... Aharenves Loabivin (2002), starring Mohamed, alongside Ali Seezan, Sheela Najeeb, Aminath Rasheedha, and Neena Saleem.

[28] In 2005, Mohamed starred alongside Ali Seezan and Sheereen Abdul Wahid in Ahmed Nimal's horror film Handhu Keytha (2005), which tells the story of a man who is enchanted by a spirit while witnessing a lunar eclipse.

[36] Mohamed then stepped into Fathimath Nahula's critically and commercially successful romantic drama television series Kalaage Haqqugaa, to play the role of Aishath Imna, a sacrificing mother and an orphan who is later abandoned by her guardian.

[10] In April 2006, Ahmed Nimal's revenge thriller Hiyani was released, featuring Mohamed as a devoted wife who seeks comfort in the company of her husband's kidnapper.

[41][40] The same year, Mohamed again collaborated with the team from Vairoalhi Ahves Sirrun, in Arifa Ibrahim's new romantic television drama series Vaguthu Faaithu Nuvanees.

[42] The film received widespread critical acclaim and attained blockbuster status at the box office,[31] making it one of the all-time highest-grossing movies in the Maldives.

[46] In her next release of the year, a family drama by Ali Shifau, Dhin Veynuge Hithaamaigaa, Mohamed featured in dual roles—as Nisha, an aspiring model who has been tormented by tempestuous in-laws, and as Aminath, a woman who dies during childbirth.

[58] The actress followed this with her directorial debut, the drama Niuma, which featured her in the titular role, alongside an ensemble cast including Yoosuf Shafeeu, Sheela Najeeb, Mohamed Manik, Ahmed Nimal, Aminath Rasheedha, and Abdulla Muaz.

[70] In 2012, the actress played a physiotherapist in Ravee Farooq romantic drama film Mihashin Furaana Dhandhen, opposite Mohamed Manik and Ali Seezan.

[79] It was followed by another family drama, Aadheys, directed by Abdul Faththaah and starring Hussain Sobah, Amira Ismail, Moosa Zakariyya, Fathimath Azifa, and Ali Azim in pivotal roles.

[88] She featured alongside an ensemble cast including Yoosuf Shafeeu, Mohamed Manik, Ahmed Saeed, and Ali Seezan, playing the role of Niufa.

[89][90] On 20 October 2017, a grand event was held to celebrate Mohamed's twenty-year-long career, at which she presented her upcoming psychological thriller Nivairoalhi and announced her retirement from acting.

[91] Starring opposite Yoosuf Shafeeu and Ahmed Asim, the actress gained weight in preparation for her role and faced major delays in post-production since she was suffering from laryngitis.

[93] Later that year, the first Maldivian anthology film was released, featuring Mohamed as the helpless wife of a drug dealer in a segment directed by Fuad, titled "Baiveriya".