[5] She is the older sister of Chiney Ogwumike, the first overall pick in the 2014 WNBA draft, who most recently played for the Sparks.

She attended Cy-Fair High School in Cypress, Texas and led them to a 5A State Championship in her senior season.

She participated in the 2008 WBCA High School All-America Game, where she scored 17 points, grabbed 6 rebounds,[9] and earned MVP honors for the White team.

[10] She averaged 16.8 points, 8.0 rebounds, 1.8 assists, 2.4 steals and 0.8 blocks per game during the 2007–08 season at Cy-Fair High School.

[13] On December 20, 2011, Ogwumike scored a career-high 42 points on 19 for 27 shooting while also grabbing 17 rebounds in a 97–80 win over the sixth-ranked Tennessee Lady Vols.

[15] Ogwumike left the Stanford Cardinal as the second all-time leading scorer for the women's basketball program, behind only Candice Wiggins.

[13] Ogwumike was a member of the USA Women's U18 team which won the gold medal at the FIBA Americas Championship in Buenos Aires, Argentina.

[17] Ogwumike continued on to the USA Women's U19 team which represented the US in the 2009 U19 World's Championship, held in Bangkok, Thailand in July and August 2009.

Ogwumike averaged 13.2 points and 5.7 rebounds per game, both second place on the team behind Elena Delle Donne.

On July 12, 2012, Ogwumike set a career-high in rebounds with 20 to go along with 22 points in a 77–74 win over the eventual WNBA champion Indiana Fever.

On September 13, 2012, she scored a season high 30 points on 10 of 15 shooting to go along with 11 rebounds in an 86–77 win over the Chicago Sky.

In the regular season finale on September 20, 2012, Ogwumike matched her teammate Candace Parker for team highs in both points and rebounds with each player earning 22 and 11, respectively, in a 92–76 win over the defending WNBA champion Minnesota Lynx.

[30] With a supporting cast of Candace Parker and Kristi Toliver, the Sparks were a championship contender in the league with a 26–8 record.

On August 18, 2017, Ogwumike scored a season-high 32 points along with 10 rebounds in a 115–106 double overtime victory over the Chicago Sky.

The Sparks would go on to advance to the Finals for the second season in a row, after defeating the Phoenix Mercury in a 3-game sweep, setting up a rematch with the Lynx.

The Sparks finished off the season as the number 3 seed with a 22–12 record, receiving a bye to the second round.

In the second round elimination game, the Sparks defeated the defending champions Seattle Storm 92–69.

[48] In February 2024, Ogwumike joined the WNBA Changemakers Collective and their collaboration with VOICEINSPORT (VIS) as a mentor, "aimed at keeping girls in sport and developing diverse leaders on the court and beyond the game.

Ogwumike has recruited several female athletes to join the organization and has committed to shifting its focus to women's reproductive rights for the 2024 election cycle.