"No Matter What Sign You Are" is a song released for Diana Ross & the Supremes by the Motown label.

Originally intended to be Diana Ross & the Supremes' final single before the departure of Diana Ross and penned by Berry Gordy, the song failed to fulfil Gordy's expectations as the single did not reach the top 20 in either the US and UK, peaking at 31 and 37 respectively in July 1969.

As with most singles released under this billing of the group, session singers perform the backing vocals on the recorded single as opposed to Supremes group members at the time, Mary Wilson and Cindy Birdsong.

[citation needed] It was recorded in 1983 by Russell Grant and the Starlettes.

It was sampled in 1989 by the Beastie Boys on "Shake Your Rump" from their acclaimed second album Paul's Boutique.