"No More Mr. Nice Guy" is a song by American rock band Alice Cooper, released in 1973 as a single off their sixth studio album Billion Dollar Babies (1973).

Cooper wrote the song lyrics about the reactions of his mother's church group to his stage performances, saying that there were worse things that he could do with his life and that the "gloves were off now".

Cooper made a cameo appearance while performing the song in the film adaptation of the TV series Dark Shadows.

For his 2024 album Solid Rock Revival, Cooper changed the lyrics for a kid-friendly song "Now, I'm Mr. Nice Guy".

The song appears in the Family Guy episode Jungle Love, during a scene where Chris gets paddled by Mayor Adam West as part of the "freshman hunt".