Each stage is set up like a racetrack as the character will return to the starting point after each lap.

The characters that are not under the player's control will attempt to hinder the avatar's progress in ways such as throwing dice, turning on electrical wire, and making fruit appear out of nowhere, making the evasion of such obstacles a primary concern of the player.

A game element called a "trick tile" places the dominoes effectively by input of the Circle, X, Triangle, or Square button.

Score is increased by activating the trick tiles in a shorter time and in as long of a chain as possible.

[6] Next Generation said that "for puzzle-savvy players, the combination of technique, luck, quirky surrealism, and clever designs in Mr. Domino gives the game just enough of a hook to incite addiction.