Dave Meyers directed the song's music video in Los Angeles, which portrays Trina and Tweet going on a shopping spree.

While this sexually explicit content was the focus of critical discussion, some music journalists identified "No Panties" with female empowerment, and Tweet said its message was refusing one-night stands and only having sex in a relationship.

Missy Elliott contributed to two songs for Trina's second studio album Diamond Princess (2002): "No Panties" and "Rewind That Back".

[6] While reviewing Diamond Princess for The Northern Echo, Andrew White stated that explicit hip hop tracks such as "Nasty Bitch" and "No Panties" represented the album's overall tone.

[5] Trina raps in what Rolling Stone's Arion Berger characterized as a "choppy, workmanlike rhyme flow",[7] and Tweet sings the chorus.

[9] Steve Jones for USA Today noted that Trina "uses booty as currency to accumulate power and pleasure" throughout Diamond Princess.

[16] One of the vinyl and CD releases contained the explicit, clean, instrumental, and acappella versions,[17][18] while another had an alternative tracklist including the bonus track "Get It" —featuring Deuce Poppi—as its B-side.

[2] In the Edmonton Journal, Sandra Sperounes noted that the video does not include women without panties despite the song's title, calling it a "case of false advertising".

[27] The music video uses the clean version of the single,[28] which Chuck Taylor described as incomprehensible due to the amount of edits and explicit language removed.

[34] While negatively reviewing Diamond Princess, Slant Magazine's Sal Cinquemani dismissed the single as not "even remotely as erotic" as "Oops (Oh My)".

[35] Chuck Taylor panned it as one of "the most tasteless records that has ever been pressed to plastic", and wrote that it provides another example to "blast the entertainment industry for irresponsibly marketing to youths".

[36] Wes Woods II of The Desert Sun thought it sounded too much like an Elliott song, and believed Trina was mostly overshadowed by her collaborators throughout Diamond Princess.

[39] In a 2014 Newsweek article, Victoria Bekiempis wrote that she developed a "larger-than-life rapper persona" by recording tracks with titles like "No Panties" and "Killin You Hoes".

[40] Three years later, SF Weekly's Jessie Schiewe highlighted "B R Right" and "No Panties" as the "most salacious and sexually explicit" songs from Diamond Princess.