No Side Effects is a double album by American jazz saxophonist Roscoe Mitchell which was released in 2006 on the French RogueArt label.

He leads a trio with Harrison Bankead on bass and cello and Vincent Davis on drums.

In his review for AllMusic, Alain Drouot states "Mitchell achieves a fine equilibrium between introspection, angularity, and intensity...

The performance has a timeless quality since Mitchell only tries to fulfill his artistic mission, makes no concession to trends, and refuses to compromise with his ideas.

"[1] The All About Jazz review by Marc Medwin says "Mitchell's recordings can elicit a deeply intuitive but ultimately inexplicable sense of unification in the face of superficial diversity, and this newest double disc is no exception.