The event is best remembered for its final match, which saw Eddie Guerrero defeat WWE Champion Brock Lesnar to win the title, his top wrestling achievement before his death in 2005.

[7][8] On the February 2 episode of Raw, Sheriff Steve Austin gave Goldberg the option of attending No Way Out by giving him a front-row ticket.

[9][10] On the February 5 episode of SmackDown!, the storyline between Guerrero and Lesnar was enhanced when they began a brawl after an in-ring interview segment.

[11][12] On the February 5 episode of SmackDown!, General manager Paul Heyman scheduled a triple threat match between Big Show, Kurt Angle and John Cena for No Way Out.

[11][12] The rivalry continued to develop on the February 12 episode of SmackDown!, when Angle was scheduled to team with Guerrero to face Big Show and Lesnar, but was found unconscious backstage.

[13][14] In February, WWE Cruiserweight Champion Rey Mysterio produced "Crossing Borders", which was No Way Out's official theme song.

[13][14] Before the event began and aired live on pay-per-view, Tajiri, Sakoda and Akio defeated Último Dragón, Billy Kidman, and Paul London in a 6-Man Tag Team Match on Sunday Night Heat.

The challengers had the advantage until Hotty clotheslined the Bashams, causing them to flip over the top ring rope and into ringside.

During the second sequence of the move, Guerrero grabbed Mysterio's legs and achieved a position with his shoulders spread so as to win both a pinfall and the WWE Cruiserweight title.

For the duration of the match, The Big Show, who stood at 7 feet 2 inches (2.18 m) and weighed 500 pounds (230 kg), used his body size to his advantage as he squashed, or easily and quickly performed moves on, Cena and Angle.

Lesnar then attempted to take advantage of the referee's state, as he went to retrieve the WWE title belt to hit Guerrero.

As Goldberg retreated, Guerrero countered Lesnar's second F5 into a DDT on the title belt while the referee regained consciousness.

Guerrero kicked the belt out of the ring to prevent the referee from seeing it and performed his Frog splash to pin Lesnar and win the WWE Championship from him.

"[19] Kevin Sowers from PWTorch described the main event between Eddie Guerrero and Brock Lesnar as "one to remember for a long time.

[27] At WrestleMania XX, Eddie Guerrero defeated Kurt Angle via pinfall and retained the WWE Championship.

[28] John "Bradshaw" Layfield (JBL), portraying a new character after the semi-retirement of his tag team partner Faarooq,[29][30] challenged Guerrero for the WWE Championship and defeated him at The Great American Bash to win the title.

[31] Guerrero failed to recapture the title from JBL in a steel cage match on the July 15 episode of SmackDown!.

Rey Mysterio and Chavo Guerrero's storyline over the WWE Cruiserweight Championship also continued, culminating in a battle royal match at WrestleMania XX involving other wrestlers.

Afterward, Charlie Haas and Rico won the WWE Tag Team Championship from Rikishi and Scotty 2 Hotty on the April 22 episode of SmackDown!.