The script was written by Luis Dawn and shows the experiences of Javier Herrera, an unlucky cardiovascular surgeon who, after being left by his wife María, must fight the problems of his love life upon not being able easily to forget his former mate.

Javier Herrera (Eugenio Derbez) is a cardiovascular surgeon whose world comes crashing down shortly after his wedding when his wife, María (Alejandra Barros) tells him that she loves someone else.

"[2] The shooting of No eres tú, soy yo lasted a total of eight weeks, from 11 April to 23 June 2009, during which time there was a production delay due to the H1N1 pandemic that spread through Mexico that year, even though no one in the cast or crew became ill.[2][4] The main filming sites were the Inner Circuit, some zones in Pedregal de San Ángel (Jardines del Pedregal) and the Colonia del Valle and Colonia Narvarte neighborhoods in Mexico City.

[13] Due to this last development, No eres tú, soy yo became the ninth highest-grossing film in the history of Mexican cinema, exceeding in gains the productions Arráncame la vida (2008; 97 million MXN) and Amores perros (2000).

I am very thankful to the people, who have taken two films past the 100 million mark [referring to La misma luna], and in the top ten, has me fascinated, I can't believe it.