[4] As a teenager, she earned a drama scholarship from the Tel Aviv Museum of Art and acted in several stage productions and television shows.

[4] Tishby began to achieve fame in Israel in the 1990s, appearing on the Israeli television drama, Ramat Aviv Gimmel[2] and starring as Anita in a production of West Side Story at the Habima Theatre.

[4] By 2006, Tishby had appeared in a series of television roles on shows like Star Trek, Nip/Tuck, CSI: Crime Scene Investigation, The 4400, and Charmed.

[12] Tishby was responsible for the development of adaptations for A Touch Away,[14] as well as Life Isn't Everything,[15] which was renamed Divorce: A Love Story for the American version.

[3][17] Specifically, Tishby has harshly criticized the BDS movement, referring to the principles behind its cause as "misinformation, disinformation, manipulation, elimination of history and flat-out lies.

In the book, Tishby takes a Zionist stance and criticizes the Boycott, Divestment and Sanctions (BDS) movement as it pertains to the Israeli–Palestinian conflict.

[19] In April 2022, Tishby was appointed by then-Prime Minister Yair Lapid as Special Envoy for Combating Antisemitism and the Delegitimization of Israel, the first person to serve in the newly created position.

[21] In April 2023, she was dismissed from the position after she spoke out against the judicial reform proposed by the new government of re-elected Prime Minister Benjamin Netanyahu.

She called on social media platforms to increase content moderation, adopt the IHRA definition of antisemitism, and provide active reporting mechanisms.

[24] In 2024, Simon & Schuster published her second book on antisemitism, co-written with African-American activist Emmanuel Acho, titled Uncomfortable Conversations with a Jew.