Originally, the show focused around friends Noah Nicholson, Alex Kirby, Ricky Davis, and Chance Counter.

The idea for Noah's Arc originated in 2003 when Patrik-Ian Polk attended a Los Angeles Black gay pride club event.

[2][3] During production of the pilot episode, Rodney Chester – who portrays Alex in the show – used his own truck as a makeshift hair, make-up and dressing room.

The pilot, "My One Temptation", was re-written and re-shot as a two-part premiere episode,[2] and Noah's Arc became LOGO's first scripted series.

Pamela Post, Noreen Halpern, Eileen Opatut, and John Morayniss also served as executive producers for the second season.

For the title lead role, Noah Nicholson, actors Darryl Stephens and Christian Vincent were being considered.

Shaun T. Fitness, who was originally cast as Trey Iverson in the pilot episode, was replaced by Gregory Keith in the series.

The character of Junito was originally a go-go dancer before being rewritten as a doctor and later recast with Wilson Cruz assuming the role in the series.

On July 5, 2020, nearly fourteen years after the show ended, the cast reunited for Noah's Arc: The 'Rona Chronicles, an hour-long special aired on YouTube and Facebook.

In October 2008, the movie Noah's Arc: Jumping the Broom was released which picks up after series' cliffhanger finale.

The season one soundtrack was released on March 24, 2006, and features music by such artists as Joshua Radin, Gordon Chambers, Me'shell Ndegéocello, Patrik-Ian Polk, Mary Ann Tatum, and Adriana Evans.