As a child actress, she voiced the titular character in the English dub of the film Ponyo (2008), and appeared in minor roles on shows including Hannah Montana and Doc.

In 2016, she made her debut as a singer with the single "Make Me (Cry)" featuring Labrinth, which peaked at number 46 on the Billboard Hot 100.

Her siblings include Miley, Braison, Brandi, Trace, and Christopher Cyrus, who have also mostly become musicians and entertainers.

[5] At the age of 2, Cyrus began her acting career, playing Gracie Hebert on the sixth episode of her father's TV show Doc.

She sang the English version of the theme song to that film, performing alongside her co-star Frankie Jonas.

Between 2009 and 2010, Cyrus ran a webshow with her childhood best friend Emily Grace Reaves, which was titled The Noie and Ems Show.

[17] DJ Alan Walker featured Cyrus' vocals on "All Falls Down" for his first album, Different World, which was released on December 14, 2018.

"[19] On May 15, 2020, Cyrus released her second EP, The End of Everything, which AllMusic reviewer, Neil Z. Yeung described as "a vulnerable peek into the singer/songwriter's mental and emotional struggles through heartfelt and simple offerings.

She did not comment on the subject again until February 8, 2021, when she announced on her Instagram that she was about to release a joint EP with recently songwriting collaborator PJ Harding ("July", "I Got So High That I Saw Jesus", "The End Of Everything") and its first single "Dear August" was going to be out three days later.

The album was preceded by three more singles: "Mr. Percocet" released on May 13, "Ready To Go" on June 23 and "Every Beginning Ends" with Benjamin Gibbard on August 26.

After being announced in May and cancelling the European leg, Cyrus began The Hardest Part Tour on October 4.

On November 18, Cyrus and long-time producer PJ Harding released a new song, "Snow In LA".

In December 2020, Cyrus spoke out in support of the former One Direction member Harry Styles wearing a dress on the cover of Vogue after he had been criticized by conservative commentator Candace Owens.

[29][30][31] However, in doing this she called Owens a "nappy ass heaux," which briefly prompted backlash and scrutiny against Cyrus for using a racial term referring to Afro-centric hair texture.