Born in Lambeth, England, he immigrated to North America with his parents, who settled in Savannah in 1733, the first group of white settlers of the Province of Georgia.

As a youth, Jones served in the Georgia Militia under James Oglethorpe, helping to protect the province from Native Americans and the Spanish.

He married Sarah Davis in 1755, with whom he would have fourteen children, including son George Jones, who would become a United States senator from Georgia.

He was twice elected as a delegate to the Second Continental Congress in 1775, but he did not attend due to the political turmoil in Georgia and the illness of his father, who died that year.

When news reached Georgia of the Battles of Lexington and Concord, Jones and several others raided the colony's gunpowder magazine.

Noble Wimberly Jones died in Savannah in 1805 and was interred in the family vault in the old South Broad St.