In his position, Francisco sought to have the Patient Protection and Affordable Care Act (ACA) and Deferred Action for Childhood Arrivals (DACA) struck down by the courts, neither of which occurred during his tenure.

He also defended Executive Order 13769, which was a ban on travelers from predominantly Muslim countries deemed to present security risks; this was ultimately upheld by the Supreme Court in Trump v.

He later moved to the Office of Legal Counsel for the Deputy Assistant Attorney General in the United States Department of Justice, serving in that capacity from 2003 until 2005.

[11] He also argued numerous cases in the lower federal and state courts on a wide range of constitutional, civil, and criminal matters.

[8] Francisco left Jones Day when he was appointed by President Donald Trump to the position of Principal Deputy Solicitor General for the United States, effective January 23, 2017.

[18] Francisco received an ethics waiver on April 24, 2018, which relieved him of a previous obligation to recuse himself from any investigation in which his former employer, law firm Jones Day, was involved.

As Solicitor General, Francisco sought to have the Affordable Care Act (Obamacare) and the Deferred Action for Childhood Arrivals (DACA) struck down.

[23] He sought to prevent Congress from accessing a redacted version of Special Counsel Robert Mueller's report into Russian interference in the 2016 election.