In 1999, as a student at Lehigh Carbon Community College, her disability from Reflex Sympathetic Dystrophy (RSD) began to slow her down, and she was forced to leave school.

[3] In December 2006, she won a gold and silver at the U.S. Open Table Tennis Championship in Las Vegas.

[5] Nir-Kistler won two silver medals at the 2007 Parapan American Games in Rio de Janeiro in both table tennis singles and doubles.

[7] She had several outstanding coaches and training partners, including Jason Brader, owner of the well-known FASST Performance Center in the Lehigh Valley, John Larson, Head Coach of the Emmaus Aquatic Club (EMAC), and George Frick, owner of A&H Sporting Goods, who often acted as a sponsor.

[1] She won a bronze medal in 100 metres (330 ft) breaststroke on September 5, 2012 with a time of 1:50.75 at the 2012 Summer Paralympics.

[1] In 2016, at the age of 37, she qualified for the U.S. Paralympic swimming team in the 100 breaststroke, 50 butterfly, and 50 freestyle at the summer trials in Charlotte, North Carolina.

However, the Olympic Committee notified her 10 hours before her takeoff time that her pulmonologist decided it was not advisable for her to compete since she had not yet thoroughly recovered from a bout of pneumonia.