She is a member of the Liberal Party and served as the Assistant Minister for Regional Development and Territories from 2019 until May 2022, following the appointment of the Albanese ministry.

In 2017, the South West Football League announced that it would name the best and fairest award in its women's competition the Nola Marino Medal.

Turnbull subsequently appointed her Chief Government Whip in the House of Representatives, in place of Scott Buchholz.

[5][6] In the lead-up to the 2016 federal election, Marino was challenged for Liberal preselection by Ben Small, the president of the party's Bunbury branch.

[7] After the 2019 federal election, Marino was appointed Assistant Minister for Regional Development and Territories in the Morrison government.