Nomafrench Mbombo (born 6 September 1966) is a South African academic and politician who has been a Member of the Western Cape Provincial Parliament since 2014, representing the Democratic Alliance.

[4] Before being involved in politics, she worked as an associate professor at the Faculty of Community and Health Sciences Department of the University of the Western Cape.

[4] She has also served as a member of various organisations, such as the National Committee of Confidential Enquiries on Maternal Death, NEPAD, and the UN Office of Human Rights: Women & Gender Directorate.

[4] As of 2024, Mbombo was bestowed the title of Honorary Professor through the School of Nursing at the University of the Western Cape, which further highlights her legacy in the healthcare sector.

Premier Helen Zille appointed Mbombo to the post of Western Cape Provincial Minister of Cultural Affairs and Sport.

[8] In 2018, incumbent Democratic Alliance Women's Network Federal Leader Denise Robinson announced that she would not seek re-election to another term.

[15] In February 2023, Mbombo was officially named the Patron of the University of Cape Town's Global Surgery Programme, which was established to help create an environment that will empower leaders in their respective fields to be change agents in the health sector.