[1] As per Federal Aviation Administration records, the airport had 62,785 passenger boardings (enplanements) in 2022.

[4][5] In World War II, the civilian Nome Airport shared use of the runway with Marks Army Airfield for transfer of Lend-Lease aircraft to the Soviet Union and in 1942, for air defense of the western coast of Alaska.

Marks AFB closed in 1950 and an air base squadron was at Nome Airport until December 1956.

[1] For the 12-month period ending December 31, 2020, the airport had 27,450 aircraft operations, an average of 75 per day: 54% air taxi, 34% general aviation, 6% scheduled commercial, and 5% military.

In Call of Duty: Modern Warfare 2, Nome Airport (referred to as "Sand Bravo" in the game) is featured as one of the targets of Russia during its invasion of the United States by "70 bogies".