Alexander Knox plays Wilhelm Grimm, a Nazi officer who is on trial, and the story unfolds through the eyes of several witnesses, including a Catholic priest, Father Warecki (Henry Travers), Grimm's brother Karl (Erik Rolf) and Marja Pacierkowski (Marsha Hunt), a woman to whom he was once engaged.

Taunted by the school's pupils, who say he is not fit to marry any Polish woman, he molests one of them, Anna, a young girl.

The rape is blamed on her young male friend, Jan Stys, but Wilhelm's fiancée accidentally stumbles on the truth from Anna.

When World War II starts, Grimm becomes the commander of the occupying force of the same village where he had previously lived.

His nephew Willie, whom Wilhelm asserts that he treats as his own son, is now serving under him and pursuing Marja's daughter, Janina.

When Janina also dies, Grimm's nephew renounces his Nazi allegiance, having realized what an evil path Wilhelm has led him on.

He brought on his former partner Burt Kelly to associate produce, who suggested The House of the Seven Gables screenwriter Lester Cole[4] to adapt the original story by Joseph Than and Alfred Neumann.

[6] To ensure the film be exhibited it had to conform to the usual Production Code Administration (PCA) for morality and be submitted for review with the U.S. State Department's Office of Information (OWI) for wartime values.

[6] The PCA passed the film and the OWI gave it an enthusiastic greenlight stating: “By projecting the pledges made by President Roosevelt, Winston Churchill, and other United Nations leaders, that those guilty of atrocities and violations of international law will be tried and punished, new hope could be given to the peoples of those countries now occupied by Axis forces.

[...] The first picture dealing with the punishment of Nazi war criminals to be made in Hollywood, None Shall Escape has emerged as a thoughtful and intelligent examination of this important postwar problem.”[6] The film wanted to represent the Tribunal of the Warsaw District accurately during all stages as it was some of the first ever seen of humanity held accountable for its acts.

He was filming newsreels in Hungary when the Germans invaded Poland on September 1, 1939, and was immediately sent to cover the fighting on the German-Polish front.