Based in Los Angeles, Weisser is a founding member of Odyssey Theatre Ensemble, the ProVisional Theater, and the Padua Playwrights Festival.

[2] A long-time collaborator of Murray Mednick, he originated the role of the Trickester in the playwright's epic seven-hour Coyote Cycle, and has starred in numerous American and European theatrical productions, including opposite Ed Harris in Ronald Harwood's Taking Sides[3] and John O'Keefe's Times Like These, where he received an Ovation Award, an LA Weekly Theater Award and an L.A.

[4][5] Besides his extensive stage work, Weisser is also a prolific film and television actor, with over 90 credits to his name.

Chiefly a character actor, he has starred in well-known and acclaimed films including Midnight Express, The Thing, Chaplin, Hocus Pocus, Schindler's List, and Pollock, and numerous titles directed by Albert Pyun.

He had a memorable guest role in "Madrigal" (a fifth season episode of Breaking Bad), reprised in Better Call Saul, and had provided voice-over and motion capture to a number of video games such as Medal of Honor: Allied Assault and Wolfenstein II: The New Colossus.