He co-created with writers Gerard Jones and Len Strazewski the Malibu Comics Ultraverse flagship hero Prime, and both wrote and drew the Malibu-published series featuring his original character Metaphysique.

His family subsequently moved to Houghton, Michigan, and the local newspaper The Daily Mining Gazette profiled him in 1976 as "Norm Breyfogle: Near Master Cartoonist at 16".

While in high school, he produced Tech-Team,[6] a comic commissioned by local Michigan Technological University.

[9] This was followed by several issues of First Comics's American Flagg, penciling a back-up story titled "Bob Violence" in 1985.

[21] He spent 2003 penciling and inking the title Black Tide, published by Angel Gate Press.

Breyfogle produced illustrations for a wide variety of clients outside of the comics industry including Nike, Inc., Mojo, The Red Bulletin, Time Out, Company, Süddeutsche Zeitung Magazin, and various bands such as 12 Stone Toddler, among many others.

In 2007, he provided art for the main story interiors and the covers for the comic book title The Danger's Dozen.

[22] Starting in 2006, he began a working relationship with Mazz Press, contributing stand-alone illustrations to two novels by Stephen Pytak, The .40 Caliber Mousehunt and The Wild Damned.

[26] On December 18, 2014, Breyfogle suffered a stroke that cut off blood flow to part of his brain,[3] causing paralysis on his left side.

[3][27] In July 2015 writer/novelist Glenn Hauman and writer/editor Bob Greenberger set up an Indiegogo campaign to raise $10,000 to defray the cost of Breyfogle's therapy, which involved producing a 280-page trade paperback reprinting issues #3–11 of Whisper, a 1986 First Comics series created by Steven Grant, which Breyfogle illustrated.