Reedus rose to prominence for his portrayal of Daryl Dixon in the hit AMC horror drama series The Walking Dead (2010–2022).

Reedus also landed roles in the television series Law & Order and Hawaii Five-O and ventured into voice acting and motion capture, appearing as Sam Porter Bridges in the video games Death Stranding and Death Stranding 2: On the Beach, and Striker in the animated series Helluva Boss.

He has also starred in music videos for Lady Gaga, Marilyn Manson, Keith Richards, Radiohead, R.E.M., and Orville Peck.

[10] Reedus played Jeremy in his major film debut Mimic[11] and Mac in Giovanni Rodriguez's Red Canyon.

The Walking Dead comic creator Robert Kirkman feels "absolutely blessed Reedus has honored the show with his presence, and the way he has come in and taken over that role and defined Daryl Dixon.

Reedus reprised his role of Daryl as the lead of a spin-off series centered on his character, following the conclusion of the 11th and final season of The Walking Dead.

[20] Reedus has modeled for Prada, Yohji Yamamoto, Alessandro Dell'Acqua, Durban, Levi's, Lexus, and Morgenthal Fredrics.

[citation needed] In 2015, Reedus posed for a Cruelty Free International advertisement in support of ending cosmetic tests on animals.

Tirzah), "Gypsy Woman" by Hilary Duff, "No Cities to Love" by Sleater-Kinney, and "Curse of the Blackened Eye" by Orville Peck.

[22] Reedus is also a painter, sculptor, and photographer who has shown his artwork in galleries in New York City, Barcelona, Berlin, and Frankfurt.

[23] Reedus reprised his role as Daryl Dixon in the 2013 video game The Walking Dead: Survival Instinct, which is based on the television series.