Headquartered in Newcastle upon Tyne, NEAS provides emergency medical services to the metropolitan boroughs of Newcastle upon Tyne, Gateshead, North Tyneside, South Tyneside and City of Sunderland; the ceremonial counties of County Durham and Northumberland; and the area of North Yorkshire commonly known as Teesside.

[2] NEAS is one of ten Ambulance Trusts providing England with emergency medical services, receiving direct government funding for its role.

[7] The effect of the COVID-19 pandemic in England was that delayed ambulance response times became a "continuing theme due to the unprecedented demand the service is currently experiencing”.

[8] In January 2022 call handlers were told they should consider asking patients with suspected strokes and heart attacks to be transported by friends or family because ambulance response times were under such pressure.

[13] NEAS is to feature as the host service of the ninth and tenth seasons of the BBC TV series Ambulance, with filming taking place until April 2022.