North East ISD serves the north-central and northeast areas of Bexar County, covering about 132 square miles (340 km2).

In addition to on-campus facilities, the district owns and operates a number of sports venues.

The district signed a 50-year rent-free lease to operate Time Warner Cable Park on Wetmore Road from the City of San Antonio in 2015.

[10][11] North East ISD was the defendant in Shanley v. Northeast Independent School District, a Fifth Circuit Court of Appeals ruling which declared that North East ISD had an overly broad policy and the district's suspension of five students had interfered with their rights to free speech under the United States Constitution.

The NEISD school board declared the content, which included information about birth control and advocated for the review of marijuana laws, to be inappropriate and controversial.