In the 17th century the village was the scene of a small English Civil War siege when in 1642 Lord Grey and his parliamentary forces were gathered at Leicester.

Disappointed at Brooke, Lord Grey and his 1300 soldiers made their way to North Luffenham, destroying the nearby hamlet of Sculthorpe and surrounded the Hall.

The Hall was plundered and the parliamentary soldiers attacked the nearby church, smashing windows and defacing a statue of Henry Noel's first wife (the damage to the fingers and nose can still be seen).

The original Luffenham Hall (the village school is now on the site) was built in around 1635 and belonged to the Noel family.

Archdeacon Robert Johnson (1540–1625) was Rector of North Luffenham for 51 years, from 1574 until his death; he founded Oakham and Uppingham Schools in 1584, as well as other charitable institutions including almshouses.

The Horse & Panniers (popularly known as The Nag & Bag[citation needed]) closed in 2013, and is now a guest house.