North Main Street Historic District is a national historic district located at Graham, Alamance County, North Carolina.

It encompasses 101 contributing buildings date from the 1850s to 1949 in a predominantly residential section of Graham.

The district contains single and multi-family dwellings, two schools, one commercial building and three churches.

[2] It was added to the National Register of Historic Places in 1999.

This article about a property in Alamance County, North Carolina on the National Register of Historic Places is a stub.