North Main Street Historic District is a national historic district located at Mocksville, Davie County, North Carolina.

Also in the district are the First Methodist Church (1896), the Mocksville Graded School (1911), and the Masonic Picnic Grounds, established in 1883.

Anderson House (1903), at 665 N. Main St., was built from mail order plans of architects Barber & Klutz of Nashville, Tennessee.

It was added to the National Register of Historic Places in 1990.

This article about a property in Davie County, North Carolina on the National Register of Historic Places is a stub.