North Main Street Historic District is a national historic district located at Poplar Bluff, Butler County, Missouri.

The district developed between about 1880 and 1954, and includes representative examples of Queen Anne, Neo-Classical Revival, Colonial Revival, Late Gothic Revival, and Bungalow / American Craftsman style architecture.

Located in the district is the separately listed Moore-Dalton House.

[2] It was added to the National Register of Historic Places in 2011.

This article about a property in Butler County, Missouri on the National Register of Historic Places is a stub.