It is situated at the southern end of the City of Darebin, on St Georges Road.

[2] Northcote High has a large music and science program, and has been recognised as a significant leader in the use of learning technologies in the classroom.

Cain's repeated efforts to establish a school to provide secondary education for the then predominantly working class suburb of Northcote were finally successful, despite an environment of opposition from conservative politicians and independent principals.

[4] In the 1980s Northcote High School again began to enrol girls in response to community pressure, officially moving to co-education in 1989.

[5] Northcote High School first offered a limited Maths and Science Matriculation (final year certificate) in 1946.