Performances with prominent guest conductors have included Harry Begian, Eugene Migliaro Corporon, Frederick Fennell, Donald Hunsberger, Karel Husa, and H. Robert Reynolds.

In 2001,[6] NCB was the first band from the United States invited to perform at the Festival des Anches d’Azur in La Croix Valmer, France.

NCB has performed several educational outreach programs at area schools,[12] many summer concerts at the invitation of various communities and venues, and professional band festivals and conferences.

In 2003, NCB started its Lifetime of Music program,[13] inviting dozens of Chicago-area high school musicians to perform with the band at its Winter subscription concert in February.

NCB also awards the John P. Paynter Scholarship,[13] which provides financial assistance toward an outstanding high school musician's college education and the opportunity to solo with the band.