The St. Paul Bears folded after only two games (both loses), while the Minneapolis Ewalds decided to dropped out before the final week of the season.
Championship Game: Minneapolis Jerseys 0 vs. La Crosse Old Style Lagers 25 (November 24, 1942 in Minneapolis, MN) Lagers star Halfback Russ Cycmanick was killed in a car accident on his way to the game, while starting Guard Herman ("Max") Gay was seriously injured and had to retire from football.
[17] After the dissolution of the Tri-States Division, the league dropped the two-division format, and decided the championship solely on the regular season results.
On October 11, La Crosse decided to run the score against Madison (winning 100–0), because they wanted the Cardinals to drop out of the league, as they failed to attract former Wisconsin Badgers stars as promised.
Des Moines were able to defeat La Crosse in both meetings, finishing the season with a perfect 6–0 record and winning their first championship.