[2] It co-stars Amanda Plummer, Julia Ormond, Assumpta Serna, Anthony Higgins, Diana Quick, Michael Gough, Maia Morgenstern, Rutger Hauer and F. Murray Abraham.

Co-produced by companies from France, the United Kingdom, Germany and Romania, the film was a commercial failure and received mixed reviews.

The film recounts the life and loves of the physician, astrologer, and famed prognosticator; his encounters with medieval science at the University of Montpellier and the Inquisition; and his early struggles with his visions of the future.

Nostradamus prophesies the death of Henry II of France in a jousting match.

The film depicts Nostradamus's rise in influence, because of both his success in treating plague and his predictions, culminating in his appointment as court physician to Charles IX of France (son of Henry II).