[4][5] The species is known to occupy specific bioregions, including the Humid Arnhem-Kimberly, Sub-Humid Arnhem Kimberly, Eyrean and Mitchell-grass.

[7] In the Gibson Desert of central Australia, this species has been consistently found in excavated sand dunes, further highlighting its preference for sandy habitats.

Notaden nichollsi was originally described by George Howard Parker in 1940[5] and is classified under the family Limnodynastidae, commonly known as Australian ground frogs.

[9] Aestivation is a dormant state similar to hibernation, allowing the species to conserve energy and water during prolonged dry spells.

Research by Cartledge et al. (2006)[7] suggests that the species' water balance is more closely linked to the hygric properties of the surrounding soil rather than the formation of a cocoon.

[9] These burrows serve as shelters where the frogs can seek refuge during periods of extreme heat or dryness, as well as provide a safe environment for reproduction and the development of tadpoles.

[3] After periods of heavy rainfall, breeding occurs for this species in flooded areas characterised by sandy soils with clay-pans that fill with water.

In these temporary water bodies, the tadpole development of Notaden nichollsi can occur remarkably quickly, taking as little as 30 days.

[12] During this breeding period it has been proposed that male frogs emit their unique calls while floating within the water, attracting females for mating.

Specifically, the presence or absence of a well-defined tadpole stage in Notaden nichollsi is not yet fully documented or understood due to limited available information.