Editors at AllMusic rated this album 4 out of 5 stars, with critic Mark Deming writing that "it's all but impossible to make a bad record with Solomon Burke" and that "one listen to Nothing's Impossible confirms that [producer Willie] Mitchell's instincts were right on the money" to make "rich, strong, and gospel-influenced R&B that's sturdy enough to support Burke's earth-shaking vocals while giving the star of the show enough room to move comfortably" and that results in "R&B that's smart, passionate, and powerful, and proves the King of Rock and Soul still rules his kingdom with a sure hand".

[2] Darryl Easlea of BBC Music summed up his review that "for his final work, Willie Mitchell found a perfect partner, and Nothing’s Impossible sees him depart on a high".

[3] A piece in Billboard by Ilya Skripnikov characterized this release, "with themes of love, loneliness and longing, Burke’s raw emotional delivery and Mitchell’s rich arrangements ensure that the music penetrates to the heart and soul".

[4] Steve Slagg of PopMatters rated Nothing's Impossible a 6 out of 10, stating that it is "powerful stuff" that is "a tribute to two great musical talents, still playing at the top of their game after so many years" but "it’s nowhere near as vital as either the early works it’s drawing on or the late-career exploration it’s following".

[6] Writing for Slant Magazine, Johnathan Keefe rated this album 3.5 out of 5 stars, praising the musicianship but criticizing some tracks as weaker, stating that "it’s impressive, if not exactly surprising, that he elevates some middling songs through sheer conviction and the awesome power of his voice".