The first classes were held at the home of Don Antonio and Doña Eusebia Sousa, the generous benefactors of the Sisters.

The subjects taught were Christian Doctrines, Reading and Writing, Drawing and Painting, and Home Arts for Girls.

Father Superior, founded the Notre Dame of Cotabato, a co – educational Catholic High School which in 1948 was separated into Boys' and Girls' Departments.

The Marist Brothers, took over the administration of the Boys Department and remained in the original site of the School while the RVM Sisters, under the leadership of Sr. Ma.

It saw the completion of the four-storey Mother Ignacia Building which houses the fourth year high school classes and the air-conditioned library.

Two short term courses were offered: Hotel and Restaurant Management (2 years) and Caregiver Program (7 months).

On July 2, 2014 (Wednesday), a new school bus arrived on the campus but is only used for the annual trip to the retreat house in Davao City, Philippines.